Adipotide (FTPP | Prohibitin-Targeting Peptide 1)

Synthetic Chimeric Peptidomimetic | Laboratory Research Reference | White Adipose Vascular Biology

CKGGRAKDC-GG-D(KLAKLAK)₂ | CAS 859216-15-2 | PubChem CID 163360068

For laboratory research use only. Not for use in humans or animals.

TECHNICAL SPECIFICATIONS

PRODUCT OVERVIEW

Adipotide is a synthetic chimeric peptidomimetic studied in white adipose tissue vascular biology and PHB/ANXA2 receptor research. Its bipartite structure combines a receptor-binding sequence with a proapoptotic effector domain, separated by a GG spacer.

The N-terminal CKGGRAKDC domain is associated with PHB/ANXA2 interactions in endothelial-cell research. The D-amino-acid-containing D(KLAKLAK)₂ domain is examined in mitochondrial membrane and apoptosis assays. These mechanisms are research topics and do not establish outcomes outside the experimental system.

MATERIAL IDENTITY AND STRUCTURAL REFERENCE

Adipotide (FTPP), sequence CKGGRAKDC-GG-D(KLAKLAK)₂, includes D-amino acids in the effector domain. The free base and acetate salt have different formula and mass values. Consult the lot-specific COA to identify the supplied form and counter-ion composition.

The PubChem compound record provides structural identifiers for chemical reference. Registry information describes molecular identity and does not substitute for analytical characterization of the supplied lot.

LABORATORY RESEARCH APPLICATIONS

1. PHB/ANXA2 Receptor Characterization: Cell-based assays can examine receptor expression, peptide binding, endocytosis, and co-localization in appropriate endothelial culture systems.
2. Mitochondrial Membrane Research: Biochemical and cell-based assays can examine the D(KLAKLAK)₂ effector domain, membrane interactions, and apoptosis markers with suitable controls.
3. Fatty Acid Transport Pathways: Adipose endothelial culture systems can examine relationships among PHB/ANXA2 interactions, endocytosis, and fatty acid transport markers.
4. Structure-Activity Research: The targeting domain, spacer, and effector domain provide a structural reference for peptide design and sequence-dependent assay comparisons.

Assay findings depend on cell model, receptor expression, solvent system, concentration, and incubation conditions. Use appropriate controls and evaluate publication methods and reproducibility when interpreting literature.

WHY SOURCE FROM PROFOUND AMINOS

Chemical Identity Documentation: Sequence, CAS number, and PubChem references support comparison of catalog information with lot-specific analytical documentation.

Analytical Reference: Consult the COA for the reported HPLC and mass-spectrometry results, supplied form, and lot details.

Structural Context: The chemical diagram and sequence identify the targeting domain, spacer, and effector domain relevant to laboratory assay design.

LABORATORY HANDLING AND STORAGE

Review the SDS and supplier documentation before handling. Use appropriate laboratory PPE for peptide powders and solubilized materials. Assess solvent compatibility, peptide adsorption, and stability under the selected assay conditions.

Container material can affect peptide adsorption. Assess compatibility of polypropylene or suitable glass containers with the peptide and solvent system. Store lyophilized material at -20°C, desiccated and protected from light, according to lot-specific documentation. Minimize repeated freezing and thawing, and record handling conditions in laboratory notes.

RESEARCH USE STATEMENT

Laboratory Reagent. For laboratory research use only. Not for use in humans or animals.

CHEMICAL AND MECHANISTIC REFERENCES

• PubChem CID 163360068: molecular identity and structural records.
• Kolonin et al., Nat Med. 2004;10(6):625–632, DOI 10.1038/nm1048: targeting-domain and conjugate-design research.
• Salameh et al., JCI Insight. 2016;1(12):e86351, DOI 10.1172/jci.insight.86351: PHB/ANXA2 and fatty acid transport research.
• PMC3290000, Int. J. of Peptides, 2012: plastic and glassware considerations in peptide studies.