CJC-1295/Ipamorelin
CJC-1295 without DAC / Ipamorelin is a peptide combination for laboratory receptor-signaling research involving GHRHR and GHSR-1a assay contexts.
For laboratory research use only. Not for use in humans or animals.
Original price was: $98.00.$72.00Current price is: $72.00.
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CJC-1295 Without DAC / Ipamorelin Research Reference
For laboratory research use only. Not for use in humans or animals.
Research material overview
This combination contains two distinct peptide research compounds: CJC-1295 without DAC, commonly referenced as Modified GRF (1-29), and Ipamorelin. CJC-1295 is a growth hormone-releasing hormone receptor (GHRHR) agonist; Ipamorelin is a growth hormone secretagogue receptor (GHSR-1a) agonist. The receptor context supports laboratory investigation of separate signaling pathways and measured assay endpoints.
Chemical identity and structural references
The following listed registry values distinguish the primary compounds, salt records, and related structural references. Check batch documentation for the supplied molecular form. Related records are not specifications for this combination.
| Compound / Record | PubChem CID | CAS Number | Molecular Formula | MW (g/mol) | Research Role / Notes |
|---|---|---|---|---|---|
| CJC-1295 Without DAC / Modified GRF (1-29) ; Canonical Record | 56841945 | 863288-34-0 | C₁₅₂H₂₅₂N₄₄O₄₂ | ~3367.9 | Primary canonical CJC-1295 reference. Tetrasubstituted D-Ala²/Gln⁸/Ala¹⁵/Leu²⁷ GHRH(1-29) analog. GHRHR agonist reference. |
| CJC-1295 With DAC ; Long-Acting Comparator | 91971820 | 446262-90-4 | C₁₆₅H₂₆₉N₄₇O₄₆ | ~3647.2 | Albumin Cys34-binding DAC variant. Half-life 5.8–8.1 days. Reported value relates to the DAC-bearing reference, not the without-DAC material. |
| Ipamorelin (Free Base) | 9831659 | 170851-70-4 | C₃₈H₄₉N₉O₅ | ~711.9 | Synthetic pentapeptide ghrelin mimetic. Sequence H-Aib-His-D-2Nal-D-Phe-Lys-NH₂. Selective GHSR-1a agonist. |
| Ipamorelin Acetate | 171378556 | 1258196-85-8* | C₄₄H₆₁N₉O₁₁ | ~892 | Acetate salt form. Listed acetate CAS; some COAs use the free-base CAS. Confirm the salt form and counterion in batch documentation. |
| Sermorelin / Native GRF (1-29) ; GHRH Class Reference | 16132413 | 86168-78-7 | C₁₄₉H₂₄₆N₄₄O₄₂S | ~3357.9 | Unmodified GHRH(1-29) fragment. DPP-IV-susceptible. GHRH class structural reference. |
| Tesamorelin; GHRH Analog Reference | 16137828 | 218949-48-9 | C₂₁₅H₃₅₈N₆₆O₆₇S | ~5135.9 | 44-aa GHRH analog. Structural reference for GHRH receptor research. |
Ipamorelin sequence: H-Aib-His-D-2Nal-D-Phe-Lys-NH₂. The CJC-1295 without DAC reference contains D-Ala²/Gln⁸/Ala¹⁵/Leu²⁷ substitutions. The DAC-bearing reference binds albumin Cys34 and is structurally distinct.
Receptor signaling and assay context
| Target | Pathway | Research context |
|---|---|---|
| GHRHR, class B1 GPCR | Gαs → adenylate cyclase → cAMP → PKA → CREB | GH gene transcription and calcium-dependent exocytosis in somatotroph research models. Receptor selectivity and DPP-IV resistance are discussed in PMID 15817669. |
| GHSR-1a, class A GPCR | Gαq → phospholipase C → IP₃/DAG → intracellular Ca²⁺ release | Ipamorelin receptor selectivity and GH-secretory readouts, including cortisol, ACTH, and prolactin measurements, are described in PMID 9849822. The cited in vitro potency is approximately 1.3 nM and depends on the assay conditions. |
| GH/IGF-1 signaling | GH receptor → JAK2/STAT5b → IGF-1 transcription | Downstream receptor and transcriptional measurements require a defined model. PI3K/Akt, mTOR, and MAPK are additional signaling contexts discussed in the referenced literature. |
The two receptor pathways can converge on somatotroph secretory readouts. This mechanistic rationale does not establish additive or synergistic results for the combination. Use component controls, matched solvent systems, and direct endpoint measurements when interpreting research assays. Results for the albumin-binding CJC-1295 reference cannot be transferred to the without-DAC material.
Analytical research and evidence boundaries
Cited CJC-1295 analytical studies describe urine detection at a reported limit of detection of ≤0.5 ng/mL (PMID 41138283), blood detection (PMID 35298973), and 19 in vitro metabolites (PMID 34665524). These are method-specific findings, not batch purity or identity results. Literature for the individual components and related molecular forms does not establish measured results for this combination.
Chemical structure references
GHRH receptor analog ; molecular formula C152H252N44O42 ; CAS 863288-34-0 ; Profound Aminos research
reference 2026
receptor agonist GHSR-1a ; molecular formula C38H49N9O5 ; CAS 170851-70-4 ; Profound Aminos research
reference 2026
Laboratory documentation and handling
Confirm identity, molecular form, purity, and lot information against the batch COA. Refer to the SDS and material-specific documentation for laboratory handling, PPE, solubilization, solvent compatibility, and storage conditions. The structural reference table does not replace batch analytical documentation.
Frequently Asked Questions
What chemical entities are included in this research combination?
CJC-1295 without DAC, also called Modified GRF (1-29), is a 29-amino-acid GHRHR agonist. Ipamorelin is a pentapeptide GHSR-1a agonist. They have distinct sequences, molecular formulas, and receptor targets.
What is the intended research classification?
For laboratory research use only. Not for use in humans or animals.
How should single-component literature be interpreted?
Check the molecular form, experimental model, matrix, and measured endpoint in each source. Findings for CJC-1295 with DAC or for either component alone do not establish results for the CJC-1295 without DAC / Ipamorelin combination.
What identity information should be checked for Ipamorelin?
Check the base or salt form, CAS number, molecular formula, molecular weight, and batch COA. The listed free-base record is PubChem CID 9831659, CAS 170851-70-4, C₃₈H₄₉N₉O₅, approximately 711.9 g/mol.
What structural features identify CJC-1295 without DAC?
The listed Modified GRF (1-29) reference contains D-Ala², Gln⁸, Ala¹⁵, and Leu²⁷ substitutions. Its listed record is PubChem CID 56841945, CAS 863288-34-0, C₁₅₂H₂₅₂N₄₄O₄₂, approximately 3367.9 g/mol.
Which receptor pathways are relevant to research assays?
CJC-1295 is associated with GHRHR and Gαs/cAMP/PKA/CREB signaling. Ipamorelin is associated with GHSR-1a and Gαq/PLC/IP₃ signaling. Combined assay results require component controls and direct measurement of the selected endpoint.
What analytical research has been reported for CJC-1295?
The cited literature describes urine detection with a reported limit of detection of ≤0.5 ng/mL (PMID 41138283), blood detection (PMID 35298973), and characterization of 19 in vitro metabolites (PMID 34665524). Method suitability depends on the matrix, reference material, and validation conditions.
Reference records
- PubChem CID 56841945: pubchem.ncbi.nlm.nih.gov/compound/56841945
- PubChem CID 91971820: pubchem.ncbi.nlm.nih.gov/compound/91971820
- PubChem CID 9831659: pubchem.ncbi.nlm.nih.gov/compound/9831659
- PubChem CID 171378556: pubchem.ncbi.nlm.nih.gov/compound/171378556
- PubChem CID 16132413: pubchem.ncbi.nlm.nih.gov/compound/16132413
- PubChem CID 16137828: pubchem.ncbi.nlm.nih.gov/compound/16137828
- PMID 15817669: pubmed.ncbi.nlm.nih.gov/15817669/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 9849822: pubmed.ncbi.nlm.nih.gov/9849822/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 16352683: pubmed.ncbi.nlm.nih.gov/16352683/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 17018654: pubmed.ncbi.nlm.nih.gov/17018654/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 10496658: pubmed.ncbi.nlm.nih.gov/10496658/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 25331030: pubmed.ncbi.nlm.nih.gov/25331030/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 10373343: pubmed.ncbi.nlm.nih.gov/10373343/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 19289567: pubmed.ncbi.nlm.nih.gov/19289567/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 32801950: pubmed.ncbi.nlm.nih.gov/32801950/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 39043357: pubmed.ncbi.nlm.nih.gov/39043357/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 41490200: pubmed.ncbi.nlm.nih.gov/41490200/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 41966639: pubmed.ncbi.nlm.nih.gov/41966639/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 41880199: pubmed.ncbi.nlm.nih.gov/41880199/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 41138283: pubmed.ncbi.nlm.nih.gov/41138283/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 34665524: pubmed.ncbi.nlm.nih.gov/34665524/. Consult the original source for its molecular form, model, and experimental limitations.
- PMID 35298973: pubmed.ncbi.nlm.nih.gov/35298973/. Consult the original source for its molecular form, model, and experimental limitations.
For laboratory research use only. Not for use in humans or animals.
| Weight | 0.02 lbs |
|---|---|
| Dimensions | 1.5 × 2.75 × 1 in |
| Strength | 10mg |
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