GLP/GIP-Tz
GLP/GIP-Tz is a lyophilized dual-agonist research ligand for GIP and GLP-1 receptor assays, available in mass formats from 5mg to 120mg. Higher-mass formats support preparation of a single laboratory stock for multiple assays.
For laboratory research use only. Not for use in humans or animals.
Price range: $65.00 through $326.00
"These Statements Have Not Been Evaluated By The Food And Drug Administration. This Product Is Not Intended To Diagnose, Treat, Cure Or Prevent Any Disease."
Disclaimer : For Research Use Only (RUO). Not for use in humans or animals.
Product Overview
This product is the synthetic peptide ligand known as GLP/GIP-Tz, supplied across a range of mass units (5mg–120mg) to suit different laboratory scales. It is a linear 39- amino acid chain that functions as a Dual-Agonist, targeting two distinct incretin receptor pathways simultaneously. Smaller units suit single-assay or exploratory use, while higher-mass units are engineered for high-throughput laboratories: they allow researchers to create a single concentrated Stock Solution, supporting consistent stock preparation for cell culture assays, without pooling multiple smaller containers. Research Mechanism: In laboratory receptor research, this ligand is utilized to study:
- Synergistic Signaling : How activating the GIP receptor alongside the GLP-1 receptor alters cellular energy homeostasis.
- Lipid Substrate Utilization : Investigating how dual-pathway modulation influences adipocyte (fat cell) metabolism in vitro.
- Receptor Kinetics : Measuring binding affinity without the interference of insulinogenic feedback loops.
- Synergistic Mechanism of Action : Distinct from mono-target ligands, GLP/GIP-Tz exhibits simultaneous affinity for both GIP and GLP-1 recognition sites. This dual-receptor occupancy modulates intracellular cAMP flux, facilitating the investigation of synergistic signaling pathways in isolated cell cultures.”
Chemical Diagram
Chemical Diagram of GLP/GIP-Tz
2D chemical structure of GLP/GIP-Tz lyophilized reagent showing peptide backbone and lipid chain modification GLP/GIP-Tz Lyophilized Reagent Vial for Stock Solution – GIP/GLP-1 Receptor Affinity Ligand- CAS 2023788-19-2
Regulatory Status : Research Use Only (RUO). Not for use in humans or animals.
Comparative Research Context :
Receptor Ligand Research Context
| Feature | GLP/GIP-Tz (Dual-A) | GLP-1-Sm (Single-A) | GLP/GIP/GLC-Rt (Triple-A) |
|---|---|---|---|
| Target Receptors | GIP + GLP-1 | GLP-1 Only | GIP + GLP-1 + Glucagon |
| Primary Action | Synergistic Modulation | Agonist Signaling | Multi-Pathway Flux |
| Research Focus | Energy Homeostasis | GLP-1R Signaling | Multi-Receptor Signaling |
| Assay Type | Dual-Receptor Binding | Single-Receptor Binding | Triple-Receptor Binding |
WHY SOURCE FROM PROFOUND AMINOS
1. Format Flexibility, Single-Stock Option
Higher-mass GLP/GIP-Tz formats (75mg and above) support preparation of a single laboratory stock without pooling multiple smaller containers. Formats from 5mg to 40mg remain available for smaller-scale assays. Stock homogeneity and reproducibility must be assessed under the selected experimental conditions.
2. Cold-Chain Integrity
Peptide ligands are sensitive to thermal degradation. We use monitored cold-chain handling within the USA, with shipment from a climate-controlled facility to your laboratory.
3. Sequence Integrity Verification
Mass spectrometry supports identity characterization of the 39-amino acid peptide. Consult the lot-specific COA for reported analytical results.
REGULATORY & COMPLIANCE STATEMENT (RUO)
Regulatory Classification & Usage Disclaimer :
This product is strictly classified as a Research Use Only (RUO) reagent.
Chemical Reference Standard: It is supplied solely for in-vitro testing and laboratory calibration.
Research Classification: Laboratory Reagent for research assays.
Laboratory Handling: Use appropriate PPE, including gloves and eyewear, during solubilization and materials handling.
Safety Data : Refer to CAS 2023788-19-2 safety sheets before use.
Research Use: For laboratory research use only. Not for use in humans or animals.
Frequently Asked Questions
Q1: Is this product intended for human use?
No. This is a Chemical Reference Material for laboratory research use only. Not for use in humans or animals.
Q2: What do the different mass formats (5mg–120mg) mean?
Each number refers to the total mass of lyophilized material in the container. Smaller formats support smaller-scale assays, while higher-mass formats support laboratory stock preparation across multiple experiments.
Q3: Which solvent systems are relevant to the lyophilized material?
Solution or an assay-compatible buffer may be used as laboratory solvent systems. Assess solubility, stability, solvent compatibility, and the concentration required for the selected assay. Consult the SDS and lot-specific documentation.
Q4: How should receptor selectivity be assessed?
GLP/GIP-Tz is studied as a GIP and GLP-1 receptor agonist. Assess selectivity using appropriate receptor-binding assays, controls, and off-target panels. Molecular identity alone does not establish an absence of off-target interactions.
Q5: Why is the powder quantity visually small?
Lyophilization removes much of the water and can leave a compact cake. Visual volume can vary and does not provide a reliable measure of mass. Refer to the labeled mass and lot-specific documentation.
Q6: Which receptor class is relevant to this ligand?
GIP and GLP-1 receptors are G-protein-coupled receptors. Laboratory assays can examine receptor engagement and downstream signaling. Claims about other receptor families require specific assay evidence.
Q7: What information determines the shelf life?
Consult the lot-specific documentation for the storage period and conditions of the lyophilized material. Stability after solubilization depends on the solvent system, concentration, temperature, and handling conditions.
Q8: Do you provide a COA?
Yes. Each batch includes a Certificate of Analysis reporting purity and identity characterization by HPLC and mass spectrometry. Consult the lot-specific COA for the reported results.
Q9: What is the intended research setting?
This reagent is supplied for in vitro testing and laboratory research. All handling should follow the SDS and applicable institutional laboratory procedures. Not for use in humans or animals.
Q10: What are the storage conditions for this research reagent?
Store lyophilized powder at -20°C, desiccated and protected from light. Consult the supplier documentation and institutional laboratory procedures for materials handling requirements.
GLP/GIP-Tz (High-Mass) | Dual-Agonist Ligand | CAS 2023788-19-2 | Profound Aminos
TECHNICAL SPECIFICATIONS
- Product Ref : GLP/GIP-Tz (Dual-Agonist Research Reagent)
- Chemical Class : Dual-Agonist Peptide Ligand
- CAS Number : 2023788-19-2
- Molecular Formula : C₂₂₅H₃₄₈N₄₈O₆₈
- Molecular Weight : ~4813.53 g/mol
- Sequence Length : 39 Amino Acids
- Format : Lyophilized Filtered Cake
- Mass Format : Available in 12 mass units, 5mg–120mg (see strength selector)
- Purity : ≥99% (RP-HPLC Verified)
- Solubility : Soluble in Solution / Buffer
- Storage : -20°C (Desiccated)
Disclaimer : For Research Use Only (RUO). Not for use in humans or animals.
Product Overview
This product is the synthetic peptide ligand known as GLP/GIP-Tz, supplied across a range of mass units (5mg–120mg) to suit different laboratory scales. It is a linear 39- amino acid chain that functions as a Dual-Agonist, targeting two distinct incretin receptor pathways simultaneously. Smaller units suit single-assay or exploratory use, while higher-mass units are engineered for high-throughput laboratories: they allow researchers to create a single concentrated Stock Solution, supporting consistent stock preparation for cell culture assays, without pooling multiple smaller containers. Research Mechanism: In laboratory receptor research, this ligand is utilized to study:
- Synergistic Signaling : How activating the GIP receptor alongside the GLP-1 receptor alters cellular energy homeostasis.
- Lipid Substrate Utilization : Investigating how dual-pathway modulation influences adipocyte (fat cell) metabolism in vitro.
- Receptor Kinetics : Measuring binding affinity without the interference of insulinogenic feedback loops.
- Synergistic Mechanism of Action : Distinct from mono-target ligands, GLP/GIP-Tz exhibits simultaneous affinity for both GIP and GLP-1 recognition sites. This dual-receptor occupancy modulates intracellular cAMP flux, facilitating the investigation of synergistic signaling pathways in isolated cell cultures.”
Chemical Diagram
Chemical Diagram of GLP/GIP-Tz
2D chemical structure of GLP/GIP-Tz lyophilized reagent showing peptide backbone and lipid chain modification GLP/GIP-Tz Lyophilized Reagent Vial for Stock Solution – GIP/GLP-1 Receptor Affinity Ligand- CAS 2023788-19-2
Regulatory Status : Research Use Only (RUO). Not for use in humans or animals.
Comparative Research Context :
Receptor Ligand Research Context
| Feature | GLP/GIP-Tz (Dual-A) | GLP-1-Sm (Single-A) | GLP/GIP/GLC-Rt (Triple-A) |
|---|---|---|---|
| Target Receptors | GIP + GLP-1 | GLP-1 Only | GIP + GLP-1 + Glucagon |
| Primary Action | Synergistic Modulation | Agonist Signaling | Multi-Pathway Flux |
| Research Focus | Energy Homeostasis | GLP-1R Signaling | Multi-Receptor Signaling |
| Assay Type | Dual-Receptor Binding | Single-Receptor Binding | Triple-Receptor Binding |
WHY SOURCE FROM PROFOUND AMINOS
1. Format Flexibility, Single-Stock Option
Higher-mass GLP/GIP-Tz formats (75mg and above) support preparation of a single laboratory stock without pooling multiple smaller containers. Formats from 5mg to 40mg remain available for smaller-scale assays. Stock homogeneity and reproducibility must be assessed under the selected experimental conditions.
2. Cold-Chain Integrity
Peptide ligands are sensitive to thermal degradation. We use monitored cold-chain handling within the USA, with shipment from a climate-controlled facility to your laboratory.
3. Sequence Integrity Verification
Mass spectrometry supports identity characterization of the 39-amino acid peptide. Consult the lot-specific COA for reported analytical results.
REGULATORY & COMPLIANCE STATEMENT (RUO)
Regulatory Classification & Usage Disclaimer :
This product is strictly classified as a Research Use Only (RUO) reagent.
Chemical Reference Standard: It is supplied solely for in-vitro testing and laboratory calibration.
Research Classification: Laboratory Reagent for research assays.
Laboratory Handling: Use appropriate PPE, including gloves and eyewear, during solubilization and materials handling.
Safety Data : Refer to CAS 2023788-19-2 safety sheets before use.
Research Use: For laboratory research use only. Not for use in humans or animals.
Frequently Asked Questions
Q1: Is this product intended for human use?
No. This is a Chemical Reference Material for laboratory research use only. Not for use in humans or animals.
Q2: What do the different mass formats (5mg–120mg) mean?
Each number refers to the total mass of lyophilized material in the container. Smaller formats support smaller-scale assays, while higher-mass formats support laboratory stock preparation across multiple experiments.
Q3: Which solvent systems are relevant to the lyophilized material?
Solution or an assay-compatible buffer may be used as laboratory solvent systems. Assess solubility, stability, solvent compatibility, and the concentration required for the selected assay. Consult the SDS and lot-specific documentation.
Q4: How should receptor selectivity be assessed?
GLP/GIP-Tz is studied as a GIP and GLP-1 receptor agonist. Assess selectivity using appropriate receptor-binding assays, controls, and off-target panels. Molecular identity alone does not establish an absence of off-target interactions.
Q5: Why is the powder quantity visually small?
Lyophilization removes much of the water and can leave a compact cake. Visual volume can vary and does not provide a reliable measure of mass. Refer to the labeled mass and lot-specific documentation.
Q6: Which receptor class is relevant to this ligand?
GIP and GLP-1 receptors are G-protein-coupled receptors. Laboratory assays can examine receptor engagement and downstream signaling. Claims about other receptor families require specific assay evidence.
Q7: What information determines the shelf life?
Consult the lot-specific documentation for the storage period and conditions of the lyophilized material. Stability after solubilization depends on the solvent system, concentration, temperature, and handling conditions.
Q8: Do you provide a COA?
Yes. Each batch includes a Certificate of Analysis reporting purity and identity characterization by HPLC and mass spectrometry. Consult the lot-specific COA for the reported results.
Q9: What is the intended research setting?
This reagent is supplied for in vitro testing and laboratory research. All handling should follow the SDS and applicable institutional laboratory procedures. Not for use in humans or animals.
Q10: What are the storage conditions for this research reagent?
Store lyophilized powder at -20°C, desiccated and protected from light. Consult the supplier documentation and institutional laboratory procedures for materials handling requirements.
| Weight | N/A |
|---|---|
| Dimensions | N/A |
| Strength | 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 60mg – 3ml, 60mg – 5ml, 75mg – 5ml, 100mg – 3ml, 100mg – 5ml, 100mg – 10ml, 120mg – 10ml, 95mg – 5ml, 95mg – 3ml |
DISCLAIMER:
- Products sold on our website are meant for scientific research purposes only, designed for in vitro testing and lab experimentation exclusively. These products are not intended to be used as foods, drugs or cosmetics, any sort of bodily introduction of the products into humans or animals is strictly prohibited. They must also not be misbranded, misused, or mislabeled, or used for anything other than research and scientific investigation.
- All the products you see on the website are being sold in a lyophilized powder state (freeze-dried), in a sealed sterile vial; and should be reconstituted.
The product’s label clearly states the amount of product a vial contains; some products are offered in different variations. - The products we are selling come in a sealed vial but require additional lab equipment for proper testing.
- Though we make sure packaging, label, seals and writing does not differ from the product photos you see on our website, there is a chance for a minimal deviation.
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