Ipamorelin (RUO) | GHS-R1a Research Reagent | ≥99% Purity

Product Specifications

• Product Name: Ipamorelin (Research Grade)
• CAS Number: 170851-70-4
• Peptide Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
• Molecular Formula: C38H49N9O5
• Molecular Weight: 711.868 Da
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized crystalline powder
• Solubility: Aqueous diluent or laboratory saline system, subject to assay compatibility
• Target Receptor: Ghrelin receptor (GHS-R1a)

For laboratory research use only. Not for use in humans or animals.

Chemical Identity & Characteristics

Ipamorelin (NNC 26-0161) is a synthetic pentapeptide GHS-R1a agonist. Its defined sequence provides laboratory research context for structure-activity relationships, receptor-binding measurements, and downstream signaling assays.

Aib (α-aminoisobutyric acid): This non-proteinogenic N-terminal residue contributes steric characteristics relevant to backbone conformation and enzymatic susceptibility studies.

D-2-Nal (D-2-naphthylalanine): The bulky naphthalene group provides structural context for hydrophobic receptor interactions. The existing binding specification lists Ki = 2.3 nM; interpret this value according to the assay method and experimental conditions.

D-Isomer Chirality: D-2-Nal and D-Phe provide research context for protease susceptibility and peptide-stability measurements. Evaluate stability in the selected experimental matrix.

Receptor Selectivity and Assay Endpoints

Laboratory investigations may characterize GHS-R1a binding, GH-associated secretory readouts, and ACTH, cortisol, or prolactin measurements within defined assay systems. Concentration-response data and appropriate controls are needed to interpret receptor selectivity and off-target responses.

The supplied material’s identity does not establish the magnitude or absence of any downstream response. Interpret receptor-binding and secretory measurements according to the experimental model and analytical conditions.

Laboratory Research Context

• GHS-R1a receptor binding and downstream signaling assays
• Structure-activity relationship measurements involving the pentapeptide scaffold
• Cell-based GH, ACTH, cortisol, and prolactin analytical readouts
• Temporal signaling, receptor desensitization, and repeated-exposure assays
• Peptide identity, enzymatic susceptibility, and stability measurements

Assay Characterization

Chemical Identity of Ipamorelin

The retained structure image provides a chemical reference for Ipamorelin (C38H49N9O5) and the listed pentapeptide sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2.

Why Researchers Source Ipamorelin from Profound Aminos

• Lot-Specific Documentation: Each shipment includes a Certificate of Analysis with HPLC chromatograms and mass-spectrometry data for identity and ≥99% purity.
• USA Cold-Chain Materials Handling: The listed storage condition is −20°C, with shipping from the USA facility. Evaluate material stability alongside lot-specific storage information.
• Endotoxin Monitoring: The listed screening limit is below 1.0 EU/mg. Review the batch result when evaluating the reagent for sensitive in-vitro assays.
• Batch Traceability: Batch identifiers support documentation and material tracking in longitudinal laboratory studies.

Research Use and Laboratory Storage

For laboratory research use only. Not for use in humans or animals.

The existing long-term storage specification lists −20°C to −80°C for lyophilized powder, with a listed 12–24-month stability period. Confirm storage and expiry information for the supplied lot in the batch documentation. Assess solvent compatibility and stability before solution-based assays.

Frequently Asked Questions

Which receptor pathways provide research context for Ipamorelin?

Ipamorelin is a synthetic GHS-R1a agonist. GHS-R1a and GHRH receptor signaling provide distinct contexts for laboratory receptor-interaction and downstream signaling assays. Combined effects require evaluation within the specific experimental system.

What temporal measurements are relevant to signaling assays?

Time-course assays can examine receptor responses, secretory readouts, and changes after repeated experimental exposure. Sampling intervals and controls depend on the cell model and assay method. These observations do not establish a general timing recommendation.

How should the lyophilized material be stored?

The existing long-term storage specification lists −20°C to −80°C and a 12–24-month stability period for lyophilized powder. Confirm lot-specific storage and expiry information in the batch documentation. For laboratory research use only. Not for use in humans or animals.

For laboratory research use only. Not for use in humans or animals.