KLOW | Four-Component Laboratory Peptide Blend

GHK-Cu 50 mg + BPC-157 10 mg + TB-500 10 mg + KPV 10 mg

Technical Specifications

• Format: Lyophilized powder in a sealed laboratory container
• Total listed content: 80 mg
• GHK-Cu: CAS 89030-95-5; PubChem 378611; C14H23CuN6O4; 50 mg
• BPC-157: CAS 137525-51-0; PubChem 9941957; C62H98N16O22; 10 mg
• TB-500: Listed thymosin beta-4 material, CAS 77591-33-4; PubChem 45382195; C212H350N56O78S; ~4963 g/mol; 43 amino acids; TMSB4X reference; 10 mg
• KPV (Lys-Pro-Val): CAS 69630-60-0; PubChem 122130; 10 mg
• Purity: ≥99%, RP-HPLC per fraction
• Identity: LC-MS characterization of four fractions
• Endotoxin: <0.25 EU, LAL method
• Solvent context: Aqueous laboratory buffer / Solution
• Lyophilized storage: 2–8°C, desiccated and light-protected
• Solution storage: −20°C, single-use aliquots

For laboratory research use only. Not for use in humans or animals.

Product Overview

KLOW combines four peptide materials at a listed mass ratio of 50:10:10:10. Component-level research provides contexts for extracellular-matrix markers, vascular signaling, actin-associated measurements, and NF-κB pathways. Composition alone does not establish simultaneous or synergistic effects.

Component Research Contexts

GHK-Cu

GHK-Cu is a copper complex of glycyl-histidyl-lysine. The existing coordination description lists histidine imidazole, glycine amino, and amide nitrogen interactions with Cu²⁺ and a log stability constant of 16.44. Laboratory contexts include collagen I/III, glycosaminoglycan, fibroblast, and superoxide-dismutase measurements.

BPC-157

The listed pentadecapeptide provides context for VEGFR2/Akt-eNOS, FAK/paxillin, endothelial migration, vascular tube assays, and nitric-oxide measurements. Interpret pathway observations within the exact material and model studied.

TB-500 Material

The existing specification describes a 43-amino-acid thymosin beta-4 material and an LKKTET actin-associated sequence reference. Confirm full sequence, residue numbering, and molecular form against batch documentation. Research contexts include G-actin/F-actin relationships, cytoskeletal organization, fibroblast motility, and VEGF-associated measurements.

The retained image is labeled as an amylin-analogue illustration. It does not document the TB-500 component or establish the blend’s molecular identity.

KPV

KPV is a Lys-Pro-Val tripeptide associated with the C-terminal α-MSH sequence. Research contexts include importin-α3, p65/RelA nuclear localization, NF-κB reporter assays, MAPK measurements, and PepT1-associated cellular uptake.

Analytical and Multi-Component Assays

Use component controls and defined experimental conditions when assessing the blend. Matrix composition, peptide concentrations, solvent compatibility, and cell models affect interpretation. The addition of KPV supplies a separate molecular component; it does not by itself establish a particular pathway response.

Why Profound Aminos

Listed batch documentation includes RP-HPLC purity and LC-MS molecular identity and sequence information for each fraction. Review actual results before material selection and concentration calculations.

The formulation is described as prepared in one lyophilization run at a fixed mass ratio. Homogeneity and aliquot content require analytical assessment. USA domestic cold-chain handling is listed from a climate-controlled facility.

Laboratory Handling

Use gloves, a lab coat, and protective eyewear during solubilization and handling. Consult component SDS information for CAS 89030-95-5, 137525-51-0, 77591-33-4, and 69630-60-0.

Store lyophilized material at 2–8°C, desiccated and protected from light. Store solutions at −20°C in single-use aliquots and limit repeated freezing and thawing. Assess compatibility in the selected aqueous laboratory buffer.

Existing Reference Identifiers

The existing bibliography identifies Sung et al., Tissue and Cell 2025;95:102837; PMID 18061177; PMC2431115; PMC12313605; PMID 39963574; Front Endocrinol 2021;12:767785; and PMC6073405. Consult original records for the molecular materials, models, and endpoints studied.

For laboratory research use only. Not for use in humans or animals.