Melanotan 1 (MT-1) | Linear MC1R Research Reagent

Product Specifications

• Chemical name: [Nle4, D-Phe7]-α-MSH
• Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
• Class: Synthetic linear α-MSH analogue
• Receptor context: MC1R-associated signaling
• Formula: C78H111N21O19
• Molecular weight: 1646.85 g/mol
• CAS: 75921-69-6
• Purity: ≥99%, HPLC verified, with D-Phe7 stereochemical testing
• Format: Lyophilized white powder, acetate salt
• Listed solvent systems: Solution, laboratory saline, dilute acetic acid

For laboratory research use only. Not for use in humans or animals.

Description

MT-1 is a linear 13-amino-acid melanocortin research peptide. Nle4, D-Phe7, and the terminal modifications provide structural context for receptor binding and enzymatic susceptibility assays. Evaluate selectivity and stability under the specific assay conditions.

Laboratory endpoints include MC1R binding kinetics, MITF expression, tyrosinase activity, eumelanin measurements, reactive-oxygen markers, and nucleotide excision repair (NER)-associated readouts in defined cellular systems.

Experimental and Analytical Use

• MC1R binding and signal-transduction assays
• MC3R/MC4R interaction measurements with suitable controls
• Melanocyte signaling and tyrosinase kinetics
• UV-associated cellular redox and DNA-marker assays
• LC-MS/MS impurity and metabolite profiling

Detection and Characterization

The existing analytical description lists [M+2H]²⁺ at m/z 823.9 for the intact parent peptide. Enzymatic cleavage and terminal-fragment measurements provide additional characterization endpoints. Identify fragments using the actual method and mass data rather than assuming their sequence from the intact scaffold.

Handling and Stability

The listed solvent systems include Solution, laboratory saline, and dilute 0.1% acetic acid. Evaluate pH compatibility and peptide stability within the chosen method. Store lyophilized material at −20°C and laboratory solutions at −80°C when retained for later assays. Limit repeated freezing and thawing.

Chemical Structure

Features / Highlights

• Linear 13-amino-acid melanocortin scaffold
• Nle4 and D-Phe7 structural substitutions
• N-acetyl and C-amide terminal modifications
• Listed ≥99% HPLC purity
• MC1R receptor and analytical assay context

Why Profound Aminos

Listed analytical documentation includes D-phenylalanine stereochemical assessment, impurity characterization, and mass-spectrometry identity information. Review batch data when assessing the material for receptor-binding assays.

Existing Literature Context

The existing bibliography identifies Hadley et al. (1998), 11:575–595, for melanocortin scaffold research and Breindahl et al. (2015), 7(2):164–172, for analytical characterization of related materials. Confirm the molecular forms and experimental systems in the original records.

FAQs

What laboratory research contexts are listed for MT-1?

MT-1 provides context for MC1R binding, melanocyte signaling, MITF expression, tyrosinase kinetics, eumelanin measurements, and cellular UV-response assays.

What molecular features describe MT-1?

MT-1 is a linear 13-amino-acid α-MSH analogue with Nle4 and D-Phe7 substitutions and N-acetyl/C-amide termini. The listed formula is C78H111N21O19 and molecular weight is 1646.85 g/mol.

What is the intended use of the material?

For laboratory research use only. Not for use in humans or animals.

What storage conditions are listed?

Store lyophilized acetate powder at −20°C, protected from light and moisture. Laboratory solutions are listed for immediate assay use or storage at −80°C. Limit repeated freezing and thawing and evaluate solvent-system stability.

What analytical detection method is described?

The existing LC-MS/MS description lists the doubly charged precursor ion [M+2H]²⁺ at m/z 823.9. Interpret detection according to the matrix, method, instrument settings, and validation conditions.

For laboratory research use only. Not for use in humans or animals.