Melanotan 2 (MT-2) | Cyclic Heptapeptide Laboratory Reagent

Product Specifications

• Chemical name: Ac-Nle-cyclo-NH2
• Systematic name: N-acetyl-L-norleucyl-L-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2→7)-lactam
• Class: Synthetic cyclic lactam analogue of α-MSH
• Receptors: MC1R, MC3R, MC4R, MC5R
• Formula: C50H69N15O9
• Molecular weight: 1024.2 g/mol
• CAS: 121062-08-6
• Purity: ≥98%, HPLC verified, with D-Phe stereochemical assessment
• Format: Lyophilized white powder, acetate salt
• Solvent systems: Solution or dilute acetic acid; pH-dependent stability

For laboratory research use only. Not for use in humans or animals.

Description

MT-2 is a synthetic cyclic heptapeptide for melanocortin receptor research. Its D-phenylalanine residue and lactam bridge provide structural context for receptor-binding and enzymatic susceptibility assays. The existing scaffold description identifies Asp5/Lys10 and D-Phe7 using α-MSH residue numbering; the systematic name uses the fragment’s (2→7)-lactam numbering.

Laboratory endpoints include ligand binding constants, signal transduction, tyrosinase activity in melanocyte systems, MC4R-associated cellular signaling, and metabolic pathway measurements. Evaluate each response within the selected cell model and analytical controls.

Experimental and Analytical Use

• MC1R and MC4R receptor-binding kinetics
• Melanocortin signal-transduction assays
• Cellular metabolic and redox measurements
• Peptide impurity and metabolite characterization
• Aggregation and immunological interaction assays

Analytical Detection

The existing LC-MS/MS method description lists the intact peptide’s doubly charged precursor ion [M+2H]²⁺ at m/z 513. Deamidation and C-terminal cleavage products provide additional analytical endpoints. Interpret detection according to the matrix, extraction method, instrument settings, and validation conditions.

Handling and Stability

The existing solvent information lists Solution and dilute 0.1% acetic acid. Assess solubility and pH compatibility for the chosen assay. Extreme pH can affect hydrolysis and peptide integrity. Store lyophilized material at −20°C and laboratory solutions at −80°C when retained for later assays. Limit repeated freezing and thawing.

Molecular Reference Images

Analytical Characterization

Listed testing includes HPLC, mass-spectrometry identity confirmation, D-phenylalanine stereochemical assessment, and examination of truncated sequences, aspartimide byproducts, and ring-opening degradation. Review the batch documentation for actual analytical results. Purity and scaffold identity alone do not guarantee reproducibility or solution stability.

Why Profound Aminos

Profound Aminos supplies MT-2 acetate for receptor-binding and peptide-characterization assays. Listed documentation covers stereochemical validation, impurity characterization, and mass identity matching the cyclic scaffold at 1024.2 Da.

Existing Literature Identifiers

The existing bibliography lists Breindahl et al. (2015), 7(2):164–172, for LC-UV-MS/MS characterization; Hadley et al. (1998), 11:575–595, for melanocortin scaffold research; Vanhee et al., Talanta (2015), 144:63–70, for analytical identification; and Navarro et al. (2002), 72:149, for melanocortin signaling research. Consult original records for exact materials and experimental systems.

FAQs

What laboratory research contexts are listed for MT-2?

MT-2 provides context for MC1R, MC3R, MC4R, and MC5R binding, melanogenesis-associated signaling, and cellular metabolic pathway assays.

What structural features describe MT-2?

MT-2 is a cyclic heptapeptide lactam analogue of α-MSH, with N-acetyl and C-amidated termini. The listed molecular formula is C50H69N15O9 and molecular weight is 1024.2 g/mol.

What analytical characterization is listed?

The listed purity is ≥98%, HPLC verified, with D-phenylalanine stereochemical assessment and mass-spectrometry identity information. Review batch results for the supplied material.

What storage conditions are listed?

Store lyophilized acetate material at −20°C, protected from light and moisture. Laboratory solutions are listed for immediate assay use or storage at −80°C. Assess stability in the selected solvent system and limit repeated freezing and thawing.

What is the intended use of the supplied material?

For laboratory research use only. Not for use in humans or animals.

For laboratory research use only. Not for use in humans or animals.