Selank (Synthetic Tuftsin Analog): Neuropeptide & Neuroimmune Research Peptide

Product Specifications

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• Molecular Weight: ~863 Da
• Purity: ≥99% (HPLC verified)
• Solubility: Solution or PBS, subject to assay compatibility
• Storage: −20°C, protected from light and moisture
• For laboratory research use only. Not for use in humans or animals.

Description

Selank is a synthetic heptapeptide analog of tuftsin, a molecule associated with an IgG heavy-chain fragment. Its research context includes neurotransmitter signaling, gene-expression measurements, and immune-system signaling in controlled laboratory assays.

The seven-amino-acid sequence provides a defined material for investigating neurochemical pathways and neuroimmune interactions. The listed purity is ≥99%, HPLC verified. Interpret assay results using material characterization, appropriate controls, and defined experimental conditions.

Neurobiological research contexts include GABAergic transmission and serotonergic pathways, with measurements of receptor responses and gene transcription related to serotonin synthesis and receptor regulation. These assay endpoints provide a basis for examining inhibitory signaling without implying a particular behavioral outcome.

BDNF-related signaling and transcription markers associated with synaptic plasticity provide additional research endpoints. Gene-expression measurements can help characterize responses within the selected experimental system; they do not by themselves establish a direct receptor interaction.

Neuroimmune research includes cytokine measurements involving IL-6, IL-10, and TNF-α. Laboratory models can examine relationships between cytokine signaling, cellular stress-response markers, and neural signaling under defined assay conditions.

Neuropeptide Origins and Pathway Research

Selank is a tuftsin analog, while Semax is an ACTH(4-10) fragment analog. Their distinct sequences and biological origins provide separate contexts for neuropeptide studies. GABAergic and serotonergic signaling, cytokine regulation, BDNF-related expression, and enkephalin-degrading enzyme activity are research topics described in the existing bibliography. Results require interpretation for the specific compound and experimental model.

Terminal Modifications and Analytical Characterization

The existing description discusses standard Selank acetate and N-acetyl/C-amidated variants. Terminal modifications alter terminal charge characteristics and provide contexts for exopeptidase susceptibility, lipophilicity, membrane-associated measurements, and stability assays. Confirm the supplied material’s form in batch documentation before interpreting variant-related observations.

Scientific Research Areas

1. Neurotransmitter Signaling
   GABAergic and serotonergic pathway measurements and receptor-response assays.
2. Neuroimmune Interactions
   IL-6, IL-10, and TNF-α readouts in controlled cellular systems.
3. Gene Expression & Neurotrophic Factors
   BDNF-related signaling and transcription markers associated with synaptic plasticity.
4. Cellular Stress-Response Biology
   Defined laboratory measurements of stress-response pathways and immune-neural signaling.

Research Applications

1. GABAergic and serotonergic pathway assays
2. Gene-expression and neurotrophic signaling measurements
3. Cytokine and neuroimmune interaction research
4. Cellular stress-response signaling
5. Neuropeptide sequence and structural characterization
6. Peptide stability and terminal-modification assays

Features / Highlights

1. Synthetic tuftsin analog for neurotransmitter and neuroimmune research
2. Defined heptapeptide sequence
3. Listed purity of ≥99%, HPLC verified
4. Gene-expression and cytokine pathway assay context
5. Terminal-modification research context, with supplied form confirmed by batch documentation
6. For laboratory research use only. Not for use in humans or animals.

Why Profound Aminos

Profound Aminos supplies Selank for laboratory neuroscience, neuroimmune, and peptide-signaling research. Sequence, purity, mass, and identity documentation support material assessment. Laboratory evaluation of solubility and stability depends on the solvent system and storage conditions. Temperature-controlled packaging is part of materials handling.

For laboratory research use only. Not for use in humans or animals.

Review / Key References

The existing bibliography lists the following references for neuropeptide pathway research. Consult the original publications for compound identity, assay conditions, and the endpoints measured.

1. Andreeva L. A., et al. (2005). GABAergic transmission research.
2. Dolotov O. V., et al. (2007). Gene-expression research in neurochemical models.
3. Kovaleva A., et al. (2020). Neuropeptide signaling research.
4. Kost N. V., et al. (2001). Enkephalin-degrading enzyme research involving Selank and Semax.
5. Narkevich V. B., et al. (2008). Monoamine pathway research.
6. Inozemtsev A. N., et al. (2012). Comparative neuropeptide research.
7. Ashmarin I. P., et al. (1998). Tuftsin-derived analog and immune-signaling research.

Storage Instructions

• Store at −20°C
• Keep sealed and protected from light and moisture
• Limit repeated freezing and thawing

FAQs

What is Selank used for in research?

Selank provides laboratory research context for GABAergic and serotonergic signaling, neuroimmune interactions, cytokine measurements, and gene-expression pathways.

What is the structural relationship between Selank and tuftsin?

Selank is a synthetic tuftsin analog with the seven-amino-acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. Tuftsin is associated with an IgG heavy-chain fragment.

What biological origins are described for Selank and Semax?

Selank is a tuftsin analog, while Semax is an ACTH(4-10) fragment analog. Their distinct sequences and origins provide separate contexts for neuropeptide pathway research.

What is the intended use of the supplied Selank?

For laboratory research use only. Not for use in humans or animals.

Why is analytical purity relevant to laboratory assays?

The listed purity is ≥99%, HPLC verified. Purity and identity data inform material assessment and interpretation of assay results, but do not guarantee reproducibility.

Research Materials Supplier

Profound Aminos supplies RUO-designated peptides and related laboratory materials for benchtop research, assay development, analytical methods, and proteomic studies.

For laboratory research use only. Not for use in humans or animals.

Chemical structure