Semax (ACTH 4–10 Analogue) | Laboratory Research Peptide

Product Specifications

1. Peptide identity: Synthetic heptapeptide.
2. Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP).
3. Molecular weight: Approximately 809 Da.
4. Purity: ≥99%, HPLC verified.
5. Laboratory solvent context: Aqueous diluent or PBS.
6. Storage: −20 °C, protected from light and moisture.

For laboratory research use only. Not for use in humans or animals.

Identity and Laboratory Research Scope

Semax is a synthetic heptapeptide described as an ACTH(4–10) analogue. The sequence MEHFPGP provides a defined material for analytical characterization and neuromolecular research.

The component literature discusses BDNF and NGF expression, synaptic plasticity, oxidative-stress pathways, and gene regulation. These provide laboratory research contexts and do not establish outcomes for the supplied reagent.

Transcriptomic and Proteomic Assay Context

RNA sequencing and microarray methods are used to examine gene-expression readouts associated with neuronal metabolism, mitochondrial signaling, vascular responses, cytokine regulation, and synaptic structure. Proteomic methods examine oxidative-stress-responsive proteins and cytoskeletal elements.

The listed research literature includes ischemia-reperfusion and oxidative-stress models, with antioxidant-enzyme activity, inflammatory-signaling measurements, and microvascular readouts. Retinal-cell and dopaminergic-signaling studies provide additional context for experimental neuroscience.

Research Applications

1. BDNF and NGF signaling measurements.
2. Cellular responses associated with ischemia-reperfusion research.
3. Oxidative-stress and antioxidant-enzyme assays.
4. Transcriptomic and proteomic profiling in neuronal models.
5. Mitochondrial and synaptic-function measurements.
6. Comparative pathway studies involving Selank, P21, and BDNF mimetic research compounds.

Analytical Documentation and Lot Traceability

Profound Aminos lists ≥99% HPLC-verified purity, molecular-weight verification, and sequence-identity documentation for Semax. Each lot includes analytical data and storage guidance to support laboratory traceability and assay evaluation.

Temperature-protected packaging and controlled storage are listed for material handling. Evaluate experimental suitability using the lot documentation and controls appropriate to the selected assay.

Selected Research Literature

The original bibliography references Dergunova et al. (2021, Molecular Neurobiology) for neurotrophic-factor expression; Filippenkov et al. (2020, Frontiers in Neuroscience) for transcriptomic measurements; Dergunova et al. (2023, International Journal of Molecular Sciences) for gene-expression research; and Sudarkina et al. (2021, Neuroscience Letters) for proteomic profiling.

Additional cited research contexts include ACTH-derived peptide neuroregulation (Koroleva and Myasoedov, 2018), cytokine measurements (Vyunova et al., 2016), retinal oxidative-stress models (Fedorov et al., 2020), experimental molecular pathways (Huo et al., 2025), neuroenergetics (Singh et al., 2025), and nervous-system peptide bioregulators (Myasoedov and Ashmarin, 2019).

Storage and Laboratory Handling

• Store at −20 °C in a tightly sealed container.
• Protect from light and moisture.
• Limit repeated freezing and thawing when managing laboratory aliquots.
• Use an aqueous diluent or PBS compatible with the analytical method and evaluate stability under the selected assay conditions.

Chemical Structure

Semax chemical-structure diagram showing the linear heptapeptide MEHFPGP, peptide bonds, and terminal carboxyl group.

Frequently Asked Questions

What laboratory research context is described for Semax?

Semax is discussed in neurotrophic-factor signaling, oxidative-stress measurements, and transcriptomic regulation in neuronal models. Listed endpoints include BDNF and NGF expression, mitochondrial signaling, cytokine measurements, and synaptic-structure readouts.

What is the structural origin of Semax?

Semax is a synthetic heptapeptide described as an ACTH(4–10) analogue. Its sequence is Met-Glu-His-Phe-Pro-Gly-Pro, or MEHFPGP, with a listed molecular weight of approximately 809 Da.

What is the intended use of the supplied material?

This material is supplied as a laboratory research reagent for analytical and in vitro assay contexts. For laboratory research use only. Not for use in humans or animals.

What analytical documentation is provided?

The listed material has at least 99% HPLC-verified purity. Lot documentation includes purity verification, molecular-weight and sequence-identity information, and storage guidance. Review the batch documentation when evaluating assay suitability.

How do the sequence references for Semax and Selank differ?

Semax is described as an ACTH-derived peptide, while Selank is described as tuftsin-derived. Their sequence origins provide distinct structural contexts for neurobiology research; results should be interpreted within each specific assay system.

For laboratory research use only. Not for use in humans or animals.