Acetyl Octapeptide-3 (SNAP-8) – Laboratory Research Reagent

TECHNICAL SPECIFICATIONS

• Product Ref: Acetyl Octapeptide-3 (Research Reagent)
• IUPAC / INCI Name: Acetyl Octapeptide-3
• Chemical Class: Synthetic peptide / Signal-modulating octapeptide
• Chemical Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
• CAS Number: 868844-74-0
• Listed Molecular Weight: ~889 g/mol
• Amino Acid Count: 8 amino acids (Octapeptide)
• Purity Standard: ≥99% (HPLC verified); MS identity confirmed; COA available on request
• Storage: Lyophilized: 2–8°C in sealed research unit
• Storage After Solubilization: Store at −20°C; single-use laboratory aliquots recommended
• Listed Shelf Life: 24 months from manufacture date when lyophilized, sealed, and stored at −20°C
• Classification: Research Use Only (RUO)

For laboratory research use only. Not for use in humans or animals.

Product Description

Overview

Acetyl Octapeptide-3 is an eight-amino-acid synthetic peptide discussed as a structural extension of Acetyl Hexapeptide-8. Its laboratory research context includes interactions involving the N-terminal fragment of SNAP-25 (Synaptosomal-Associated Protein, 25 kDa) and the SNARE complex. These molecular relationships provide endpoints for in-vitro biochemical assays.

Research Mechanism

SNARE Complex Interaction Assays: Laboratory studies examine interactions between the peptide, SNAP-25 fragments, and SNARE-complex components using cell-free biochemical binding assays.

Vesicle-Fusion Signaling Research: Defined assay systems measure signaling associated with vesicle-fusion pathways at controlled laboratory concentrations.

Barrier-Model Permeation Research: Laboratory models examine peptide permeation across stratum-corneum barriers. Permeation measurements depend on the experimental model, material characteristics, and assay conditions.

Multi-Component Assay Studies: In-vitro investigations may examine interactions alongside peptide reference compounds such as Pentapeptide-18. The presence of multiple compounds does not establish complementary or combined effects.

Chemical Diagram

Chemical Diagram of Acetyl Octapeptide-3 (SNAP-8)

Acetyl Octapeptide-3 (SNAP-8) is a lyophilized laboratory research reagent for molecular characterization and SNARE-complex signaling assays.

For laboratory research use only. Not for use in humans or animals.

The existing bibliography identifies PMC7662462 and Raphas Co. (2021) as research context. Consult the original materials for the compounds and experimental models described.

Research Compound Context

The following table retains the existing compound and pathway references. Consult the original publications for molecular identity, experimental systems, and endpoints.

WHY SOURCE FROM PROFOUND AMINOS

1. Laboratory Research Documentation: Research topics include biochemical binding, vesicle-fusion signaling, and barrier-model permeation. Evaluate these endpoints within the selected assay system and interpret them alongside appropriate controls.

2. Analytical Identity Verification: Structural characterization and stability measurements are distinct analytical questions. The supplied material should be assessed using lot-specific identity documentation and the conditions of the intended laboratory assay.

3. COA Documentation: Every batch includes a Certificate of Analysis confirming purity and identity via HPLC and mass spectrometry. Review the COA for the analytical results and specifications of the supplied lot.

RESEARCH USE AND LABORATORY HANDLING

For laboratory research use only. Not for use in humans or animals.

Research Use Classification: This compound is supplied for in-vitro biochemical testing, cellular assays, and laboratory analytical work. Research observations require interpretation within the experimental model.

Laboratory Handling: Wear appropriate personal protective equipment, including chemical-resistant gloves and eye protection, during solubilization and handling. Follow institutional safety procedures applicable to synthetic peptides. Review the Safety Data Sheet (SDS) for CAS 868844-74-0 before initiating laboratory work.

Storage and Materials Handling: The listed lyophilized storage condition is 2–8°C in a sealed research unit. The listed 24-month shelf life applies to sealed lyophilized material stored at −20°C. After solubilization, store at −20°C in single-use aliquots and assess stability in the selected solvent system. Confirm lot-specific storage and expiry information in the COA.

Frequently Asked Questions

What is the intended use of SNAP-8?

For laboratory research use only. Not for use in humans or animals.

What structural features define SNAP-8?

Acetyl Octapeptide-3 (SNAP-8) contains eight amino acids with the listed sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. The existing research description discusses it as a structural extension of Acetyl Hexapeptide-8.

What barrier properties are relevant to permeation assays?

The stratum corneum limits passive permeation of large hydrophilic peptides in barrier-model research. Interpret permeation measurements within the specific laboratory model.

What research classification applies to this material?

This material is supplied as a Research Use Only laboratory reagent for in-vitro biochemical testing, cellular assays, and analytical work.

How are concentrations selected for laboratory assays?

Select concentrations according to the specific assay method, experimental model, controls, and material characterization. Consult the methodology of relevant publications for the conditions actually studied.

What safety information should laboratories consult?

Review the Safety Data Sheet for CAS 868844-74-0 and institutional safety procedures before handling the reagent. Use appropriate chemical-resistant gloves and eye protection.

What documentation accompanies the reagent?

Batch documentation includes a Certificate of Analysis with HPLC purity and mass-spectrometry identity information. Review the COA for lot-specific specifications.

What endpoints are examined in vesicle-fusion research?

Laboratory assays examine SNARE-complex interactions and vesicle-fusion signaling. The extent of any measured modulation depends on the experimental system and assay conditions.

What is the listed shelf life of the lyophilized reagent?

The listed shelf life is 24 months from manufacture when lyophilized, sealed, and stored at −20°C, as specified in the COA. Confirm lot-specific storage and expiry information in the batch documentation.

How is the reagent stored after laboratory solubilization?

Store at −20°C using single-use laboratory aliquots, as listed in the existing handling information. Evaluate compatibility and stability in the selected solvent system.

For laboratory research use only. Not for use in humans or animals.