GLP-1-Sm
GLP-1-Sm is a modified GLP-1 receptor agonist for receptor, DPP-4 resistance, and albumin-binding research. PubChem CID 56843331 | CAS 910463-68-2 | C187H291N45O59 | MW 4113.58 g/mol.
For laboratory research use only. Not for use in humans or animals.
Price range: $74.00 through $130.00
"These Statements Have Not Been Evaluated By The Food And Drug Administration. This Product Is Not Intended To Diagnose, Treat, Cure Or Prevent Any Disease."
GLP-1-Sm (GLP-1 Receptor Agonist)
Chemical Reference Standard | PubChem CID 56843331
C187H291N45O59 | MW 4113.58 g/mol | DPP-4-Resistant GLP-1R Agonist | Albumin-Binding Modified Peptide
For laboratory research use only. Not for use in humans or animals.
PRODUCT OVERVIEW
GLP-1-Sm is a chemically modified glucagon-like peptide-1 (GLP-1) receptor agonist with a backbone derived from human GLP-1 (7-37). Its structural features support research into receptor engagement, enzymatic stability, and albumin binding.
Three modifications characterize the peptide: Aib substitution at position 8, Arg substitution at position 34, and Lys26 acylation through a hydrophilic spacer with a C18 fatty diacid chain. These features can be examined through analytical characterization and controlled laboratory assays.
CHEMICAL IDENTITY AND STRUCTURAL REFERENCE
| Identifier | Detail |
|---|---|
| Catalog Reference | GLP-1-Sm |
| PubChem CID | 56843331 |
| CAS Number | 910463-68-2 |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.58 g/mol |
| Structural Class | Modified GLP-1 peptide analogue |
| Receptor Target | GLP-1R |
| Sequence Homology | 94% homology to native human GLP-1 |
Consult PubChem CID 56843331 for complete structural identifiers, including SMILES and InChI records. Registry information describes molecular identity; lot-specific documentation describes the supplied material.
THREE-MODIFICATION DESIGN
| Modification | Position | Laboratory Research Context |
|---|---|---|
| Aib substitution | Position 8 | Resistance to DPP-4-mediated enzymatic cleavage |
| Arg substitution | Position 34 | Control of acylation selectivity by replacing Lys34 |
| C18 fatty diacid acylation through a hydrophilic spacer | Lys26 | Albumin-binding interactions and peptide stability |
RECEPTOR AND PATHWAY RESEARCH
GLP-1R is a class B G-protein-coupled receptor. Receptor engagement involves the peptide’s C-terminal region interacting with the extracellular domain and its N-terminal region engaging the transmembrane region. Downstream cAMP, PKA, and EPAC2 signaling can be examined in appropriate in vitro systems.
Research assays may examine receptor binding, concentration-response relationships, enzymatic cleavage, and albumin interactions. Assay results depend on receptor expression, cell model, solvent system, incubation conditions, and analytical controls.
ANALYTICAL QUALITY REFERENCE
| Parameter | Analytical Method | Research Purpose |
|---|---|---|
| Peptide Identity | LC-MS and peptide mapping | Assess molecular mass, sequence, and modification sites |
| Main Component and Related Impurities | RP-HPLC with UV detection | Assess chromatographic purity and synthesis-related impurities |
| Isomer Characterization | Chiral chromatography or enzymatic analysis with LC-MS | Examine amino acid isomers |
| Acylation State | Site-specific LC-MS fragmentation | Examine Lys26 modification and off-site acylation |
| Sequence Verification | Tandem MS or N-terminal analysis | Assess sequence integrity |
| Endotoxin | LAL chromogenic assay | Assess potential interference in cell-based signaling assays |
| Water Content | Karl Fischer analysis | Support peptide mass correction in concentration calculations |
| Counter-ion | Ion chromatography | Characterize counter-ion composition relevant to assay preparation |
These methods describe analytical research considerations and do not assert that every method has been performed on each lot. Consult the lot-specific COA for reported results.
LABORATORY HANDLING AND STABILITY
Review the SDS and lot-specific documentation for materials handling and storage information. Use appropriate PPE. Assess solubilization, solvent compatibility, adsorption, and stability under the selected assay conditions. Record the lot, solvent system, concentration, and handling conditions in laboratory notes.
RESEARCH LIMITATIONS
Cell-based and biochemical assay results are specific to the experimental system. Reference literature does not establish the identity, purity, or stability of a supplied lot. Use appropriate controls and analytical documentation when interpreting experimental results.
FREQUENTLY ASKED QUESTIONS
Q1: What are GLP-1-Sm’s chemical identifiers?
GLP-1-Sm is associated with PubChem CID 56843331 and CAS 910463-68-2. Its molecular formula is C187H291N45O59 and molecular weight is 4113.58 g/mol. Consult the compound record for complete structural identifiers.
Q2: What are the three structural modifications?
The modified GLP-1 backbone contains Aib at position 8, Arg at position 34, and a C18 fatty diacid attached at Lys26 through a hydrophilic spacer. These features are relevant to DPP-4 resistance, site-selective acylation, and albumin-binding research.
Q3: What is SNAC in formulation research?
SNAC is sodium N-[8-(2-hydroxybenzoyl)amino]caprylate. Laboratory formulation literature examines its effects on local pH, proteolytic stability, and epithelial permeability. This background does not establish the composition or handling conditions of this research material.
Q4: What is the research-use classification of this listing?
This listing is a Laboratory Reagent for laboratory research use only. Not for use in humans or animals.
Q5: Which analytical methods are relevant to GLP-1-Sm?
LC-MS and peptide mapping assess molecular identity and modification sites. RP-HPLC assesses the main component and related impurities. Additional methods may examine isomers, water content, counter-ions, and endotoxin where relevant to the assay.
Q6: Which receptor and pathway can be studied with GLP-1-Sm?
GLP-1-Sm is a GLP-1 receptor agonist. In vitro receptor assays can examine receptor engagement and downstream cAMP, PKA, and EPAC2 signaling. Results depend on the assay system and experimental conditions.
Q7: What laboratory handling information should be consulted?
Review the SDS and lot-specific documentation before laboratory handling. Use appropriate PPE and assess solvent compatibility, stability, and impurity or endotoxin interference for the selected assay.
Q8: Is GLP-1-Sm a growth hormone fragment?
No. GLP-1-Sm is a modified GLP-1 analogue with a GLP-1-derived backbone. It is structurally distinct from growth hormone and its fragments.
RESEARCH USE STATEMENT
Laboratory Reagent. For laboratory research use only. Not for use in humans or animals.
CHEMICAL AND STRUCTURAL REFERENCES
- PubChem CID 56843331: molecular identity and structural records.
- IUPHAR/BPS ligand record 9724: GLP-1 receptor annotation.
- Lau et al., 2015, DOI: 10.1021/acs.jmedchem.5b00726: peptide modification and albumin-binding design.
| Weight | N/A |
|---|---|
| Dimensions | N/A |
| Strength | 5mg, 10mg, 15mg, 20mg |
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The product’s label clearly states the amount of product a vial contains; some products are offered in different variations. - The products we are selling come in a sealed vial but require additional lab equipment for proper testing.
- Though we make sure packaging, label, seals and writing does not differ from the product photos you see on our website, there is a chance for a minimal deviation.
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