5 Amino 1MQ (Research Grade) – Small Molecule Reagent

TECHNICAL SPECIFICATIONS ( Research Blend)

• Product Name : 5 Amino 1MQ (Research Grade)
• Chemical Class : Methylquinolinium Derivative (Small Molecule)
• CAS Number : 42464-96-0 (Iodide Salt)
• Sequence : Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg
• Molecular Formula : C₁₀H₁₁IN₂ (Iodide Salt)
• Molecular Weight : 286.11 g/mol (Salt Form) [Ref: PubChem 2026 Update]
• Purity : ≥99% (HPLC Verified)
• State : Crystalline Powder
• Solubility : Soluble in DMSO; Moderate in Water

Technical note: Most laboratory workflows use the iodide salt form for stability. The cation alone has a MW of ~159.21 g/mol, but the functional reagent supplied is the salt (MW 286.11 g/mol). Ensure calculations account for the salt weight during stoichiometry.

Disclaimer : For Research Use Only (RUO). Not for human use.

Product Overview

Product Format : Lyophilized Crystal/Powder (Vial)
Grade : Reference Material (≥99% HPLC) | CAS: 42464-96-0

5-Amino-1MQ represents a distinct class of metabolic research chemicals. While GLP-1 agonists modulate satiety signaling, 5-Amino-1MQ operates intracellularly by inhibiting NNMT. Research indicates that elevated NNMT activity is linked to compromised NAD+ availability and increased adiposity.

By blocking this enzymatic pathway in research models, 5 Amino 1MQ is utilized to study:

1. Cellular Bioenergetics : Restoring the cytosolic NAD+/NADH ratio.
2. Adipocyte Phenotypes : Investigating the reduction of lipogenesis (fat accumulation) without killing the cell.

3. Myogenic differentiation: Published research examines myogenic differentiation markers in aged tissue models under controlled laboratory conditions.

Chemical Identity & Mechanism

Mechanism of Action : The “Methyl Sink” Blockade

NNMT Inhibition : The enzyme NNMT consumes Nicotinamide and S-Adenosylmethionine (SAMe) to produce 1-Methylnicotinamide (1-MNA). This process is often called the “Methyl Sink” because it drains the cell of energy precursors.

NAD+ Restoration : By inhibiting NNMT, 5-Amino-1MQ prevents this drainage, theoretically increasing the pool of NAD+ available for Sirtuin activation and mitochondrial function.

Adipocyte Bioenergetics : Cellular Assays (2017-2025) demonstrate that treated adipocytes show reduced volume and downregulated lipogenic gene expression.

Chemical Diagram

Chemical Diagram of 5-Amino-1MQ

5 Amino 1MQ Iodide Salt Structure | 2D Chemical Diagram | CAS 42464-96-0 | NNMT Inhibitor Reagent

Molecular Specification. The verified 2D diagram of 5-Amino-1MQ (Iodide Salt). Researchers must note the presence of the Iodide counterion shown here, which establishes the correct Molecular Weight (286.11 g/mol) for stoichiometric calculations in enzymatic assays.

Regulatory Status : Research Use Only (RUO). Not for human or animal use, diagnostic, or clinical use.

Comparative Research Context :

Metabolic Modulator Comparison

Practical Interpretation for Researchers

Select 5-Amino-1MQ for laboratory assays focused on cellular metabolism markers and NAD+ pathway readouts in controlled research models.

Select GLP/GIP-Tz (Dual-A) for incretin-based signaling models.

Note: 5-Amino-1MQ is often examined in combination research designs alongside peptides, but it acts through a distinct, non-hormonal pathway.

HANDLING & STABILITY

• Storage : Store at -20°C ideally, or cool dry place protected from light. The hydroscopic nature requires desiccation.

• Solubility: Soluble in water; DMSO is recommended for stock solutions to limit precipitation in high-concentration assays.

• Safety Warning : Contains Iodide. May cause skin and eye irritation. Use strictly in a fume hood with appropriate PPE.

Why Researchers source from PROFOUND AMINOS

1 – Validated salt stoichiometry: Some gray-market suppliers confuse the cation MW (159.21) with the salt MW (286.11), which can cause large concentration calculation errors in stock solutions. Our standard: we explicitly label and supply the iodide salt form so molar concentrations can be prepared accurately for enzymatic assays.

2 – USA cold-chain integrity: While stable at room temperature, NNMT inhibitors can degrade under extreme heat during transit. Our process: we maintain a monitored USA supply chain and ship from climate-controlled facilities to help preserve crystal lattice integrity.

3 – “Post-GLP-1” Research Ready : As the market shifts from simple satiety peptides to complex metabolic modulators, our 5-Amino-1MQ is tested specifically for NAD+ Salvage Pathway activity, aligning with the 2026 research focus on “Bioenergetic Optimization.”

REGULATORY & COMPLIANCE STATEMENT

Regulatory Classification & Usage Disclaimer: This product is strictly classified as a Chemical Reference Standard for Research Use Only (RUO) .

This material is a laboratory research reagent only. It is not a food, dietary supplement, or product for human or animal use. Any use outside controlled laboratory research is prohibited.

Research-use notice: 5-Amino-1MQ is supplied for laboratory research only. It is not for biohacking or personal use. Not for human or animal use.

Safety : The Iodide salt form is a chemical irritant.

H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.

Lab handling: Use only in a laboratory setting with nitrile gloves and safety goggles.