MK-677 (Ibutamoren) | Encapsulated Laboratory Reagent

Technical Specifications

• Class: Spiropiperidine, non-peptide GHSR1a ligand
• Listed CAS: 159752-10-0, mesylate material description
• Listed formula: C₂₇H₃₆N₄O₅S
• Listed molecular weight: 624.77 g/mol, salt-form description
• Format: Encapsulated powder aliquot in a laboratory carrier
• Listed mass tolerance: ±2%
• Listed solvents: DMSO, ethanol, deionized water

The formula, mass, salt identity, and net active content must be confirmed together against batch documentation before molar calculations. The existing product specifications are retained as listed.

For laboratory research use only. Not for use in humans or animals.

Product Overview

MK-677 is supplied as an encapsulated laboratory powder aliquot for chemical analysis and cellular assays. The carrier format provides a defined starting unit; actual assay concentrations depend on measured mass, active content, salt form, and purity.

GHSR1a binding and downstream signaling provide research contexts for this spiropiperidine scaffold. Evaluate selectivity and pathway responses in the specified experimental model.

Chemical Structure Reference

The retained diagram provides a molecular reference. Confirm the exact salt and analytical identity using batch documentation.

Receptor and Temporal Assay Context

The existing research description lists approximate model half-lives of 24 hours for MK-677, two hours for Ipamorelin, and 30 minutes for Modified GRF (1-29). These values describe different molecular materials and experimental systems. They do not establish timing requirements for an assay.

GHSR1a and GHRH receptor pathways provide distinct research contexts. Laboratory endpoints include ligand binding, intracellular signaling, secretory readouts, feedback-associated measurements, and receptor-response kinetics.

Batch Documentation and Analytical Assessment

Aliquot Mass

The listed gravimetric tolerance is ±2%. Use actual batch mass and net active content for concentration calculations. The encapsulated format does not remove the need for analytical verification where the method requires it.

Purity Records

The existing page lists HPLC values ranging from 98.2% to 99.4% across recent batches and also lists a ≥99% specification. Confirm the applicable specification and measured lot result in the COA. Batch #MK2402 is listed with a 99.1% example result.

Salt Identity

The supplied material is described as Ibutamoren mesylate. Salt identity, water content, and molecular mass are relevant to assay calculations and solvent compatibility.

Laboratory Handling and Storage

Consult the SDS associated with CAS 159752-10-0 and follow institutional laboratory safety procedures. Assess solubility and carrier compatibility in the selected DMSO, ethanol, or aqueous solvent system.

The listed shelf life is three years at room temperature in a cool, dry place. Avoid high humidity. Confirm lot-specific expiry and storage information. Hygroscopic clumping requires evaluation alongside storage history and material characterization.

Frequently Asked Questions

What receptor provides research context for MK-677?

MK-677 (Ibutamoren) is described as a non-peptide GHSR1a ligand. Receptor-binding and downstream signaling assays require defined experimental conditions and suitable controls.

What does the encapsulated format describe?

The outer shell is a laboratory carrier for a pre-measured powder aliquot. The material is supplied for analytical solubilization and in-vitro assays. For laboratory research use only. Not for use in humans or animals.

What solvents are listed for laboratory analysis?

The listed solvents are DMSO, ethanol, and deionized water. Assess carrier compatibility, solubility, and stability according to the batch material specifications and selected analytical method.

How should receptor selectivity be evaluated?

Binding and signaling measurements depend on receptor expression, assay design, concentrations, and controls. The ligand designation does not establish the absence of all off-target interactions.

What shelf life and storage conditions are listed?

The existing shelf-life specification is three years at room temperature in a cool, dry place. Avoid high humidity and confirm lot-specific expiry and storage information in batch documentation.

What pathway measurements are relevant?

Research contexts include GHSR1a-associated signaling, feedback-pathway measurements, and receptor kinetics within defined cellular assay systems.

What is the research classification?

This material is supplied as a Research Use Only chemical reference reagent for laboratory analytical and cellular assays.

What composition information is needed for assay calculations?

Use the actual aliquot mass, net active content, salt form, and lot-specific purity when calculating assay concentrations. Confirm molecular specifications in the batch documentation.

What purity information is listed?

The page lists recent HPLC batch values of 98.2% to 99.4% and also lists a ≥99% specification. These claims require reconciliation against the supplied lot COA; use the measured batch result rather than assuming a uniform purity.

Why may the powder clump?

The material is described as hygroscopic. Moisture-associated clumping is a physical observation and does not by itself establish chemical integrity. Assess the material using storage history and analytical documentation.

For laboratory research use only. Not for use in humans or animals.