SLU-PP-332 (Research Reagent Capsules)
SLU-PP-332 is a synthetic hydrazide laboratory reagent for ERRα, ERRβ, and ERRγ reporter, transcriptional, and mitochondrial assays. Listed ≥98% RP-HPLC purity, with LC-MS identity documentation. Supplied as an encapsulated laboratory powder aliquot.
For laboratory research use only. Not for use in humans or animals.
$65.00
Availability: In stock
"These Statements Have Not Been Evaluated By The Food And Drug Administration. This Product Is Not Intended To Diagnose, Treat, Cure Or Prevent Any Disease."
SLU-PP-332 | ERR Agonist Laboratory Research Reagent
Technical Specifications
- Class: Synthetic hydrazide nuclear-receptor ligand
- Name: 4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide
- Format: Encapsulated laboratory powder aliquot
- Formula: C18H14N2O2
- Molecular mass: 290.32 g/mol
- CAS: 303760-60-3
- PubChem CID: 5338394
- Receptor context: ERRα/NR3B1, ERRβ/NR3B2, ERRγ/NR3B3
- Listed EC50 values: ERRα ~98 nM; ERRβ ~230 nM; ERRγ ~430 nM, cell-based reporter assays
- Purity: ≥98%, RP-HPLC
- Identity: LC-MS characterization
- Solubility: DMSO soluble; limited aqueous solubility
- Storage: −20°C, desiccated and protected from light
For laboratory research use only. Not for use in humans or animals.
Product Overview
SLU-PP-332 is a synthetic hydrazide described as a pan-agonist of the estrogen-related receptor family. ERR-associated transcription, fatty-acid oxidation genes, mitochondrial biology, and oxidative metabolism provide laboratory assay contexts. Evaluate each isoform response within the specific model and analytical conditions.
Research Mechanisms and Assays
ERR Transcriptional Measurements
Relevant endpoints include ERR response-element reporter assays, fatty-acid oxidation gene expression, tricarboxylic-acid pathway measurements, and oxidative-phosphorylation readouts.
Mitochondrial Characterization
The existing description lists C2C12 cell-culture contexts, Seahorse XF respiration measurements, qPCR mitochondrial DNA analysis, and NDUFB8, ATP5A, and cytochrome-c protein assays. Confirm model suitability and receptor expression for the selected method.
Temporal Gene Expression
DDIT4, SLC25A25, Period 1/2, and FOXO1 provide transcriptional endpoints. The existing assay description lists peak expression at 1–3 hours and baseline-associated measurements by six hours. Interpret these time points within the specific experimental system.
Isoform and OXPHOS Assays
Isoform-selective models and reporter assays can examine ERRα, ERRβ, and ERRγ responses. Additional readouts include succinate-dehydrogenase activity, OXPHOS protein panels, mitochondrial respiration, and electron-transport measurements.
Molecular Structure
The listed scaffold comprises a hydrazide linkage between a 4-hydroxybenzene ring and naphthalene moiety. Aromatic interactions and ligand-binding contacts provide structural research questions.
Related Receptor Materials
The existing comparison lists GSK4716 with an ERRα value of ~4,900 nM, DY131 with ERRβ ~370 nM and ERRγ ~920 nM, and XCT790 as an ERRα inverse agonist. These are separate molecular materials; interpret values according to assay methods and identity documentation. Related structural labels in the original comparison should be checked against each material’s analytical record.
Why Profound Aminos
Listed batch characterization includes LC-MS identity and fragmentation data associated with the hydrazide scaffold. The original analytical description lists m/z 290.32; confirm ion assignment and actual mass data in the batch record.
The encapsulated format supplies a pre-measured laboratory aliquot. Concentration calculations require verified content and purity; format alone does not guarantee exact mass transfer or reproducibility. USA domestic cold-chain handling is listed from a climate-controlled facility.
Laboratory Handling
Use appropriate gloves, a lab coat, and protective eyewear. Review the SDS for CAS 303760-60-3. Store at −20°C, desiccated and protected from light. Assess DMSO and aqueous-buffer compatibility according to the assay requirements.
Existing Literature Context
The existing bibliography identifies Billon et al. (2023), Patch et al. (2024), PubChem CID 5338394, and reagent datasheets from Tocris and MedChemExpress. Consult original records for molecular identity, methods, and endpoints.
For laboratory research use only. Not for use in humans or animals.
| Strength | 500 mcg |
|---|---|
| Count | 100 Capsules |
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DISCLAIMER:
- Products sold on our website are meant for scientific research purposes only, designed for in vitro testing and lab experimentation exclusively. These products are not intended to be used as foods, drugs or cosmetics, any sort of bodily introduction of the products into humans or animals is strictly prohibited. They must also not be misbranded, misused, or mislabeled, or used for anything other than research and scientific investigation.
- All the products you see on the website are being sold in a lyophilized powder state (freeze-dried), in a sealed sterile vial; and should be reconstituted.
The product’s label clearly states the amount of product a vial contains; some products are offered in different variations. - The products we are selling come in a sealed vial but require additional lab equipment for proper testing.
- Though we make sure packaging, label, seals and writing does not differ from the product photos you see on our website, there is a chance for a minimal deviation.
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