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  • The Bogo Sale is valid from Wednesday 12:00 AM to Friday 11:59 PM (Central Time Zone).

  • Offer: Buy 1, Get 1 Free on eligible peptides and products automatically applied at checkout.

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What Are GLP-1 Peptides?
Sema vs. Tirz vs. Survo vs. Reta

When you compare Semaglutide, Tirzepatide, Survodutide and Retatrutide, all of these peptides are GLP-1 (glucagon-like peptide-1) agonists, but some of them use multiple mechanisms to increase energy expenditure and reduce food intake. At a high level, Semaglutide is an agonist of only the GLP-1 hormone, whereas other peptides like Survodutide and Tirzepatide target additional pathways, enhancing their therapeutic potential. These peptides have revolutionized the treatment, by mimicking or amplifying the effects of natural incretin hormones.

About Sema

Semaglutide, a GLP-1 receptor agonist, is widely recognized for its efficacy in treatment. It works by enhancing insulin secretion, suppressing glucagon release, and delaying gastric emptying¹.

About Tirz

Tirzepatide is a dual agonist that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual mechanism enhances insulin secretion, reduces glucagon levels, and slows gastric emptying, leading to improved glycemic control and significant treatment potential².

Is Survo The New Tirz?

Tap here to visit the Survodutide product page.

Survodutide is a GLP-1 and Glucagon dual-agonist under investigation by Boehringer Ingelheim that could revolutionise treatment.

Key research takeaways:

  1. Increases energy expenditure and reduces food intake.
  2. Survodutide is a dual-agonist, in addition to GLP-1 it also activates glucagon, and this is hypothesized to provide additional clinical benefits in addition to reducing body weight³.
  3. Some additional clinical benefits of Survodutide being investigated include: cardiovascular disease, chronic kidney disease, and MASH (metabolic dysfunction-associated steatohepatitis) which is a condition related to fat buildup in the liver⁴.

About Reta

Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors, making it a promising candidate for treatment⁵. This peptide amplifies the effects of incretin hormones while also leveraging glucagon’s role in energy expenditure.

References

¹Semaglutide: MedlinePlus Drug Information. medlineplus.gov. Published 2023. Accessed March 11, 2025. https://medlineplus.gov/druginfo/meds/a619057.html

²Tirzepatide: Uses, Dosage, Side Effects & Warnings. Drugs.com. Published 2025. Accessed March 11, 2025. https://www.drugs.com/tirzepatide.html

³Wharton S, le Roux CW, Kosiborod MN, et al. Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™-1 and -2). Obesity (Silver Spring). 2025; 33(1): 67-77. doi:10.1002/oby.24184

⁴Zimmermann T, Thomas L, Baader-Pagler T, et al. BI 456906: discov-ery and preclinical pharmacology of a novel GCGR/GLP-1R dual ago-nist with robust anti-obesity efficacy. Mol Metab. 2022;66:101633.

⁵Aslam U. Retatrutide: Uses, Side Effects, Availability and More. The Care Pharmacy. Published October 29, 2024. https://thecarepharmacy.com/retatrutide-uses-side-effects-availability-and-more/

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⚠️ IMPORTANT: AOD-9604 & Tesamorelin Product Notice

WARNING: AOD-9604 and Tesamorelin possess unique solubility characteristics that differ from many research peptides. Gelling, precipitation, cloudiness, and other physical appearance changes are known characteristics of AOD-9604 and Tesamorelin during sample preparation. Such observations do not indicate product failure, degradation, contamination, or loss of sample quality and do not prevent the material from being utilized for research purposes.

We do not provide reconstitution or preparation guidance. Products affected by purchaser handling, preparation methods, solvent selection, pH conditions, or storage practices are not eligible for replacement or refund.

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